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  Submit FeedbackFeedback (DB RCT)0.20[0.04-0.91]symp. case2/19610/198RRCITreatmentControlTau​2 = 0.00; I​2 = 0.0%PrEP0.20[0.04-0.91]2/19610/19880% improvementAll studies0.20[0.04-0.91]2/19610/19880% improvement1 iota-carrageenan COVID-19 5/4/21Tau​2 = 0.00; I​2 = 0.0%; Z = 2.08 (p = 0.019)Lower RiskIncreased Risk
In Vitro Varese et al., bioRxiv, doi:10.1101/2021.04.27.441512 (Preprint) (In Vitro) in vitro Iota-carrageenan prevents the replication of SARS-CoV-2 on an in vitro respiratory epithelium model
In Vitro Calu-3 (human respiratory epithelial cell line) study showing that iota-carrageenan inhibits SARS-CoV-2.
PrEP Figueroa et al., medRxiv, doi:10.1101/2021.04.13.21255409 (Preprint) symp. case, ↓79.8%, p=0.04 Efficacy of a nasal spray containing Iota-Carrageenan in the prophylaxis of COVID-19 in hospital personnel dedicated to patients care with COVID-19 disease A pragmatic multicenter, randomized, double-blind, placebo-controlled trial (CARR-COV-02)
Prophylaxis RCT with 394 healthcare workers, 196 treated with iota-carrageenan, showing significantly lower symptomatic cases with treatment. There were no deaths or hospitalizations. There was a significant number of PCR- symptomatic cas..
In Vitro Morokutti-Kurz et al., PLoS ONE, doi:10.1371/journal.pone.0237480 (Peer Reviewed) (In Vitro) in vitro Iota-carrageenan neutralizes SARS-CoV-2 and inhibits viral replication in vitro
In Vitro study showing that SARS-CoV-2 is inhibited by iota-carrageenan in a dose dependent manner and to the same extent as other respiratory viruses for which a clinical benefit has been proven. Authors note that clinical data and post ..
In Vitro Bansal et al., bioRxiv, doi:10.1101/2020.08.19.225854 (Peer Reviewed) (In Vitro) in vitro Iota-carrageenan and Xylitol inhibit SARS-CoV-2 in cell culture
In Vitro study showing that iota-carrageenan in concentrations as low as 6 µg/mL (easily achievable with existing nasal sprays) inhibits SARS-CoV-2 in Vero cell cultures.
Early Koenighofer et al., Multidisciplinary Respiratory Medicine, doi:10.1186/2049-6958-9-57 (Peer Reviewed) Carrageenan nasal spray in virus confirmed common cold: individual patient data analysis of two randomized controlled trials
Analysis of 2 RCTs concluding that carrageenan nasal spray reduced duration of virus-confirmed common colds, increased viral clearance, and reduced relapses.
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